COMMENT This is an interesting paper. I think the DNA damage response the authors report happens in a transient process, but prolonged activation of this DNA damage response may do more harm to cells. I like the aspect of phosphorylation of FAK by DNA-PK. We prev

Mary Savage on Scant α-Secretase Compensation for BACE Inhibition in Monkeys

COMMENT The primary expected therapeutic mechanism of action of BACE inhibition is to lower toxic Aβ burden in the CNS via inhibition of its synthesis from APP. This is founded on the strongest human genetic evidence possible, including identification of both ris

Jurgen Claassen on While You Were Sleeping—Synapses Forged, Amyloid Purged

COMMENT David Holtzman and Andrew Lim raise important points for future studies on this topic. Some further thoughts for those who would like to engage in a follow-up study: Despite the overnight stay in a hospital-like environment (clinical research lab) and the

Ilya Bezprozvanny on ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

COMMENT The finding of a VAPB-PTPIP51 interaction supporting the ER-mitochondria association is interesting and convincing. The effects of TDP-43 overexpression suggest a potential role for TDP-43 in modulating this ER-mitochondrial association and intracellular

Scant α-Secretase Compensation for BACE Inhibition in Monkeys

RESEARCH NEWS 2014-06-18 Research News Researchers hope they can treat or prevent Alzheimer's by blocking β-secretase (BACE), the enzyme that kick-starts production of Aβ from amyloid precursor protein. It is commonly believed that the non-amyloidogenic α-secretase takes ove

PAPER Gautam S, Karmakar S, Bose A, Chowdhury PK

β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.

Biochemistry. 2014 Jul 1;53(25):4081-3. Epub 2014 Jun 20 PubMed: 24933427

PAPER Tran HT, Chung CH, Iba M, Zhang B, Trojanowski JQ, Luk KC, Lee VM

Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.

Cell Rep. 2014 Jun 26;7(6):2054-65. Epub 2014 Jun 12 PubMed: 24931606

PAPER Gray MT, Gray DA, Woulfe JM

Reply to: alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker.

Mov Disord. 2014 Aug;29(9):1224-5. Epub 2014 Jun 13 PubMed: 24930843

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Anxiety can be a harbinger of early onset dementia.

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